Weight Loss With Medication

Do Weight Loss Medications Help?

There’s nobody out who is better than your own. It is life’s cycle that takes you through it. No matter the height, shape, or size, there are countless reasons you should be proud of it.

Few external or internal factors may drive you to try to lower your body weight, thus, wanting to improve your body image. It is related to the health issue your provider was probably warned about. First, however, you must follow the steps you can take to help you meet your health goals.

When possible, exercise and a healthy diet are ideal ways to help you lose body weight. However, if needed, medication is another way to help promote weight loss. While multiple weight loss medications are on the market, there are many promising treatments in clinical trials.

What is the newest weight loss medication in development?

Among the weight loss medicines now studied, tirzepatide is the furthest along. Tirzepatide (Mounjaro) is a weekly injectable medicine currently approved to treat Type 2 diabetes in adults. However, the manufacturer is also seeking its approval as a weight loss treatment.

In a recent phase 3 clinical trial, more than 2,500 adults living with overweight or obesity lost about 15% to 20% for the starting body weight after tirzepatide for 16 months. Another phase 3 trial is expected to wrap up by April 2023. The FDA will be reviewing the data in an expedited manner, so there’s a chance that tirzepatide to approve for weight loss sometime in 2023.

Working on tirzepatide for weight loss

Tirzepatide is known to mimic two hormones in your body:

  • GIP (glucose-dependent insulinotropic polypeptide)
  • GLP-1 (glucagon-like peptide-1)

It is the first medicine that targets receptors (chemical binding sites) for both hormones. As a result, eating less helps you feel full for a longer time.

Tirzepatide works in a way that is comparable to Wegovy, which is an injectable medication approved for weight loss right now.

Other weight loss medications studied in clinical trials

Apart from Tirzepatide, many other weight loss medications are working their way through clinical trials. Few are enrolled in the phase 3 studies, while the others are in phase 2. In general, successfully completing the phase 3 clinical trial is the last step before the medication submission for FDA approval.

  • NNC0165-1875
  • ARD-101
  • Retatrutide
  • Mazdutide
  • Ecnoglutide
  • CagriSema
  • Oral semaglutide

Medications used off-label for weight loss

There are many medications prescribed off-label for weight loss. In many cases, they are prescribed as weight loss is the side effect of these medications. These are some top examples:

  • Zonisamide (Zonegran)
  • Bupropin (Wellbutrin SR, Wellbutrin XL)
  • Topiramate (Topamax)
  • Pramlintide (Symlin)
  • Ozempic (Semaglutide)
  • Trulicity (Dulaglutide)
  • Tirzepatide
  • Metformin

What is the best weight loss medication?

One of the best weight loss medications for a person depends on their preferences, body weight goals, and medical history. The amount of time you look to take weight loss medicine is also a factor, along with its cost.

For instance, Wegovy is one of the popular once-weekly injectable options. As a result, it is helpful for people to lose more weight over time than other weight loss medicines. However, the side effects of Wegovy include diarrhea and nausea, which can be bothersome for a few people.

As weight loss medicines come with many variabilities, making an informed decision about the type of medicine you want to try is essential. Your healthcare provider can help you in narrowing down the options.


Making a lifestyle and dietary change is essential for long-term weight management. However, sometimes medication may be added to help you reach your goals. Contrave (naltrexone/bupropion), Saxenda (liraglutide), and Wegovy (semaglutide) are a few common choices. But the fact that you have several other options in the market making their way through clinical studies is also applicable. Tirzepatide is the most promising medicine.

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